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Version: 17.06d (Release date: 2017-06-26)
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Daunorubicin Hydrochloride (Code C1583)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Daunorubicin Hydrochloride

Definition: The hydrochloride salt of an anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin. Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis.

NCI-GLOSS Definition: A drug used to treat acute leukemias and some other types of cancer. It blocks a certain enzyme needed for cell division and DNA repair, and it may kill cancer cells. Cerubidine is a type of anthracycline antibiotic and a type of topoisomerase inhibitor.

Display Name: Daunorubicin Hydrochloride

Label: Daunorubicin Hydrochloride

NCI Thesaurus Code: C1583 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0282123  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-(9CI)
Cerubidin
CERUBIDINE
Cerubidine
Cloridrato de Daunorubicina
Daunoblastin
Daunoblastina
Daunoblastine
Daunomycin, hydrochloride
Daunomycin hydrochloride
daunomycin hydrochloride
Daunomycin Hydrochloride
Daunorubicin.HCl
Daunorubicini Hydrochloridum
Daunorubicin Hydrochloride
DAUNORUBICIN HYDROCHLORIDE
Daunorubicin hydrochloride
daunorubicin hydrochloride
FI-6339
L-lyxo-Hexopyranoside, 3beta-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-metldioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-,alpha-,hydrochloride
Ondena
RP-13057
Rubidomycin Hydrochloride
Rubilem

External Source Codes: 
CAS Registry Number 23541-50-6 (see NLM ChemIDplus info)
FDA UNII Code UD984I04LZ
NSC Code 82151 (see NCI DTP info)
NSC Code 83142 (see NCI DTP info)
PDQ Closed Trial Search ID 39779
PDQ Open Trial Search ID 39779 (check for NCI PDQ open clinical trial info)
UMLS CUI C0282123

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia
Chemical_Formula C27H29NO10.HCl
code C1583
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Daunomycin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1583

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