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Version: 17.08d (Release date: 2017-08-28)
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Bispecific Antibody MDX-H210 (Code C1578)

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Terms & Properties

Preferred Name: Bispecific Antibody MDX-H210

Definition: A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu-overexpressing tumor cells with potential antineoplastic activity. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody 520C9 and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody H22. This agent selectively binds to both HER2/neu-expressing tumor cells and Fc gammaRI-expressing cytotoxic effector cells, which may trigger antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis of HER2/neu-expressing tumor cells. While HER2/neu is overexpressed in a variety of epithelial malignancies, expression of Fc gammaRI is primarily found in cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells.

Label: Bispecific Antibody MDX-H210

NCI Thesaurus Code: C1578 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281736  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
520C9x22 Bispecific Antibody
520C9xH22 Bispecific Antibody
Antibody, Bispecific 520C9xH22
Bispecific Antibody 520C9 x H22
Bispecific Antibody MDX-H210
Bispecific Antibody MDXH210
BsAb 520C9x22
BsAb 520C9xH22

External Source Codes: 
PDQ Closed Trial Search ID 42227
PDQ Open Trial Search ID 42227 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281736

Other Properties:
     Name Value (qualifiers indented underneath)
code C1578
Legacy_Concept_Name Bispecific_Antibody_520C9XH22
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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