|Nolatrexed Dihydrochloride (Code C1577)|
|Terms & Properties|
Preferred Name: Nolatrexed Dihydrochloride
Definition: The dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
NCI-GLOSS Definition: A substance that is being studied in the treatment of liver cancer. It belongs to the family of drugs called thymidylate synthase inhibitors.
Label: Nolatrexed Dihydrochloride
NCI Metathesaurus Link: C0796399 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||152946-68-4 (see NLM ChemIDplus info)|
|FDA UNII Code||1XA69O733O|
|PDQ Closed Trial Search ID||42223|
|PDQ Open Trial Search ID||42223 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|