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Version: 17.12d (Release date: 2017-12-26)
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Nolatrexed Dihydrochloride (Code C1577)

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Terms & Properties

Preferred Name: Nolatrexed Dihydrochloride

Definition: The dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.

NCI-GLOSS Definition: A substance that is being studied in the treatment of liver cancer. It belongs to the family of drugs called thymidylate synthase inhibitors.

Label: Nolatrexed Dihydrochloride

NCI Thesaurus Code: C1577 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796399  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3,4-Dihydro-2-amino-6-methyl-4-oxy-5-(4-pyridylthio)-quinazoline Dihydrochloride
Nolatrexed Dihydrochloride
Nolatrexed Hydrochloride

External Source Codes: 
CAS Registry Number 152946-68-4 (see NLM ChemIDplus info)
FDA UNII Code 1XA69O733O
PDQ Closed Trial Search ID 42223
PDQ Open Trial Search ID 42223 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796399

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hepatocellular carcinoma
Chemical_Formula C14H12N4OS.2ClH
code C1577
Contributing_Source FDA
Legacy_Concept_Name Nolatrexed
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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