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Version: 17.06d (Release date: 2017-06-26)
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Sedoxantrone Trihydrochloride (Code C1576)

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Terms & Properties

Preferred Name: Sedoxantrone Trihydrochloride

Definition: The trihydrochloride salt of the anthrapyrazole antineoplastic antibiotic sedoxantrone with potential antineoplastic activity. Sedoxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. Sedoxantrone trihydrochloride binds to DNA and stops cells, including cancer cells, from repairing damage to DNA and from making more DNA, RNA, and protein. It is a type of DNA intercalator.

Label: Sedoxantrone Trihydrochloride

NCI Thesaurus Code: C1576 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281727  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2H-(1)Benzothiopyrano(4,3,2-cd)indazol-8-ol, 5-((2-aminoethyl)amino)-2-(2-(diethylamino)ethyl)-, Trihydrochloride
CI-958
CI 958
Ledoxantrone Trihydrochloride
LEDOXANTRONE TRIHYDROCHLORIDE
sedoxantrone trihydrochloride
Sedoxantrone Trihydrochloride

External Source Codes: 
CAS Registry Number 119221-49-7 (see NLM ChemIDplus info)
FDA UNII Code X9GSL37ED0
NSC Code 635371 (see NCI DTP info)
PDQ Closed Trial Search ID 42217
PDQ Open Trial Search ID 42217 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281727

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H27N5OS.3ClH
code C1576
Contributing_Source FDA
Legacy_Concept_Name Sedoxantrone_Trihydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1576

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