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Version: 17.06d (Release date: 2017-06-26)
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Disaccharide Tripeptide Glycerol Dipalmitoyl (Code C1575)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Disaccharide Tripeptide Glycerol Dipalmitoyl

Definition: A lipophilic disaccharide tripeptide derivative of muramyl dipeptide (MDP) with immunomodulatory activity. Disaccharide tripeptide glycerol dipalmitoyl (DTP-GDP)stimulates macrophage activity and increases serum levels of tumor necrosis factor alpha (TNF alpha), neopterin, interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8, and IL-12, which may activate host immune system antitumor functions. DTP-GDP may be packaged in liposomes for improved delivery. The immunomodulatory effects of this agent may be superior to those of MDP.

Display Name: Disaccharide Tripeptide Glycerol Dipalmitoyl

Label: Disaccharide Tripeptide Glycerol Dipalmitoyl

NCI Thesaurus Code: C1575 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0641098  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Disaccharide Tripeptide Glycerol Dipalmitoyl
DTP-GDP
ImmTher
Liposomal N-Acetylglucosaminyl-N-Acetyhnuramly-L-Ala-D-isoGlu-L-Ala-gylceroldipalmitoyl
N-Acetylglucosaminyl-N-acetyhnuramyl-L-Ala-isoGlu-L-Ala-glycerol Dipalmitate

External Source Codes: 
CAS Registry Number 130114-83-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42152
PDQ Open Trial Search ID 42152 (check for NCI PDQ open clinical trial info)
UMLS CUI C0641098

Other Properties:
     Name Value (qualifiers indented underneath)
code C1575
Contributing_Source CTRP
Legacy_Concept_Name Disaccharide_Tripeptide_Glycerol_Dipalmitoyl
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1575

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