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Version: 17.06d (Release date: 2017-06-26)
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Alitretinoin (Code C1574)

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Terms & Properties

Preferred Name: Alitretinoin

Definition: An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells.

NCI-GLOSS Definition: A drug being studied for cancer prevention. It belongs to the family of drugs called retinoids.

Label: Alitretinoin

NCI Thesaurus Code: C1574 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281666  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid
9-cis-RA
9-Cis-Retinoic Acid
9-cis-Retinoic Acid
9-cis Retinoic Acid
9-cis retinoic acid
9-cRA
Alitretinoin
ALITRETINOIN
ALRT1057
LGD1057
Panretin
Panretyn
Panrexin
Retinoicacid-9-cis

External Source Codes: 
CAS Registry Number 5300-03-8 (see NLM ChemIDplus info)
FDA UNII Code 1UA8E65KDZ
ChEBI ID CHEBI:50648 (see ChEBI info)
NSC Code 659772 (see NCI DTP info)
PDQ Closed Trial Search ID 42147
PDQ Open Trial Search ID 42147 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281666

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Topical treatment of cutaneous lesions in patients with AIDS-related Kaposi sarcoma
Chemical_Formula C20H28O2
code C1574
Contributing_Source FDA
Legacy_Concept_Name Alitretinoin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1574

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