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Version: 17.06d (Release date: 2017-06-26)
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Dinutuximab (Code C1570)

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Terms & Properties

Preferred Name: Dinutuximab

Definition: A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Dinutuximab binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells. GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It binds to a molecule called GD2, which is found in greater than normal amounts on some types of cancer cells. This helps cells of the immune system kill the cancer cells. It is a type of monoclonal antibody.

Display Name: Dinutuximab

Label: Dinutuximab

NCI Thesaurus Code: C1570 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281581  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ch14.18
Ch 14.18UTC
Dinutuximab
DINUTUXIMAB
MOAB Ch14.18
monoclonal antibody Ch14.18
Unituxin

External Source Codes: 
CAS Registry Number 1363687-32-4 (see NLM ChemIDplus info)
FDA UNII Code 7SQY4ZUD30
NSC Code 623408 (see NCI DTP info)
PDQ Closed Trial Search ID 42042
PDQ Open Trial Search ID 42042 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281581

Other Properties:
     Name Value (qualifiers indented underneath)
code C1570
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_Ch14_18
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1570

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