skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Safingol (Code C1568)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Safingol

Definition: A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein kinase inhibitors.

Display Name: Safingol

Label: Safingol

NCI Thesaurus Code: C1568 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281466  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S,3S)-2-Amino-1,3-Octadecanediol
Kynacyte
L-(-)-threo-Sphingnine
L-threo-2-Amino-1,3-octadecanediol
L-Threo-Dihydrosphingosine
L-threo-dihydrosphingosine
Safingol
safingol
SAFINGOL
SPC-100270
Sphinganine

External Source Codes: 
CAS Registry Number 15639-50-6 (see NLM ChemIDplus info)
FDA UNII Code OWA98U788S
NSC Code 714503 (see NCI DTP info)
PDQ Closed Trial Search ID 41910
PDQ Open Trial Search ID 41910 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281466

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H39NO2
code C1568
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dihydrosphingosine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1568

Mainbox Bottom