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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Amphotericin B (Code C1566)

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Terms & Properties

Preferred Name: Liposomal Amphotericin B

Definition: A liposome-encapsulated formulation of the polyene antifungal antibiotic amphotericin B produced by the bacterium Streptomyces nodosus with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, and alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Compared to amphotericin B alone, liposomal delivery of amphotericin B allows for a greater drug concentration in target tissues while decreasing systemic side effects.

Display Name: Liposomal Amphotericin B

Label: Liposomal Amphotericin B

NCI Thesaurus Code: C1566 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1145701  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Amphotericin B-Lipid Complex
Amphotericin B Liposomal
Lipid Complex, Amphotericin B
Liposomal Amphotericin B

External Source Codes: 
PDQ Closed Trial Search ID 43048
PDQ Open Trial Search ID 43048 (check for NCI PDQ open clinical trial info)
UMLS CUI C1145701

Other Properties:
     Name Value (qualifiers indented underneath)
code C1566
Contributing_Source CTRP
Legacy_Concept_Name Amphotericin_B-Lipid_Complex
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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