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Version: 17.12d (Release date: 2017-12-26)
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Dexverapamil (Code C1563)

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Terms & Properties

Preferred Name: Dexverapamil

Definition: The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04)

Label: Dexverapamil

NCI Thesaurus Code: C1563 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0280858  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
R Verapamil

External Source Codes: 
CAS Registry Number 38321-02-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 41269
PDQ Open Trial Search ID 41269 (check for NCI PDQ open clinical trial info)
UMLS CUI C0280858

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H38N2O4
code C1563
Contributing_Source FDA
Legacy_Concept_Name Dexverapamil
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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