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Version: 17.06d (Release date: 2017-06-26)
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Dexverapamil (Code C1563)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dexverapamil

Definition: The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04)

Label: Dexverapamil

NCI Thesaurus Code: C1563 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0280858  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dexverapamil
DEXVERAPAMIL
R-Verapamil
R Verapamil

External Source Codes: 
CAS Registry Number 38321-02-7 (see NLM ChemIDplus info)
FDA UNII Code QR5PYD126V
PDQ Closed Trial Search ID 41269
PDQ Open Trial Search ID 41269 (check for NCI PDQ open clinical trial info)
UMLS CUI C0280858

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H38N2O4
code C1563
Contributing_Source FDA
Legacy_Concept_Name Dexverapamil
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1563

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