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Version: 17.08d (Release date: 2017-08-28)
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Brequinar (Code C1560)

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Terms & Properties

Preferred Name: Brequinar

Definition: A synthetic quinolinecarboxylic acid analogue with antineoplastic properties. Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis. This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04)

Label: Brequinar

NCI Thesaurus Code: C1560 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0280509  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic Acid

External Source Codes: 
CAS Registry Number 96187-53-0 (see NLM ChemIDplus info)
FDA UNII Code 5XL19F49H6
PDQ Closed Trial Search ID 40886
PDQ Open Trial Search ID 40886 (check for NCI PDQ open clinical trial info)
UMLS CUI C0280509

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H15F2NO2
code C1560
Contributing_Source FDA
Legacy_Concept_Name Brequinar
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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