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Version: 17.06d (Release date: 2017-06-26)
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Levoleucovorin (Code C1559)

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Terms & Properties

Preferred Name: Levoleucovorin

Definition: The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. (NCI04)

Display Name: Levoleucovorin

Label: Levoleucovorin

NCI Thesaurus Code: C1559 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2721771  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CL-307,782
Elvorine, Isovorin, Levofolene, Levorin
Isovorin
L-5-Formyltetrahydrofolate
L-Leucovorin
Levofolinate
Levofolinic acid
Levoleucovorin
LEVOLEUCOVORIN

External Source Codes: 
CAS Registry Number 58-05-9 (see NLM ChemIDplus info)
FDA UNII Code 990S25980Y
ChEBI ID CHEBI:63606 (see ChEBI info)
PDQ Closed Trial Search ID 40490
PDQ Open Trial Search ID 40490 (check for NCI PDQ open clinical trial info)
UMLS CUI C2721771

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C20H23N7O7
code C1559
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name L-Leucovorin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1559

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