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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Human Interleukin-15 (Code C1545)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Human Interleukin-15

Definition: A recombinant agent that is chemically identical or similar to the endogenous form of the human cytokine interleukin-15 (IL-15) with immunomodulating activity. IL-15, secreted by mononuclear phagocytes (and some other cell types) following viral infection, regulates T and natural killer cell activation and proliferation. This cytokine induces activation of transcription activators STAT3, STAT5, and STAT6 via JAK kinase signal transduction pathways in mast cells, T cells, and dendritic epidermal T cells. IL-15 and interleukin-2 (IL-2) are structurally similar and share many biological activities; both may bind to common hematopoietin receptor subunits, negatively regulating each other's activity. CD8+ memory T cell number has been shown to be regulated by a balance between IL-15 and IL-2.

Display Name: Recombinant Human Interleukin-15

Label: Recombinant Human Interleukin-15

NCI Thesaurus Code: C1545 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1522569  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IL15
Interleukin 15
Recombinant Human Interleukin-15
rhIL-15
rIL15

External Source Codes: 
PDQ Closed Trial Search ID 661035
PDQ Open Trial Search ID 661035 (check for NCI PDQ open clinical trial info)
UMLS CUI C1522569

Other Properties:
     Name Value (qualifiers indented underneath)
code C1545
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interleukin-15
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1545

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