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Version: 16.11d (Release date: 2016-11-28)
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Romidepsin (Code C1544)

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Terms & Properties

Preferred Name: Romidepsin

Definition: A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia-induced angiogenesis and depletes several heat shock protein 90 (Hsp90)-dependent oncoproteins.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. Romidepsin is a type of depsipeptide and histone deacetylase inhibitor.

Display Name: Romidepsin

Label: Romidepsin

NCI Thesaurus Code: C1544 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527027  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Antibiotic FR 901228
Depsipeptide
depsipeptide
FK228
FR901228
Istodax
L-Valine, N-(3-Hydroxy-7-Mercapto-1-Oxo-4-Heptenyl)-D-Valyl-D-Cysteinyl-(Z)-2,3 -Didehydro-2-Aminobutanoyl-, xi-Lactone, Cyclic (1-2)-Disulfide, (S-(E))-
L-Valine, N- (3-hydroxy-7-mercapto-1-oxo-4-heptenyl)valyl- cysteinyl-2, 3-didehydro-2-aminobutanoyl-,xi-lactone, cyclic (1-2)-disulfide
N-[(3S,4E)-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4-1) Lactone, Cyclic
N-[(3S,4E)-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4->1) Lactone, Cyclic
Romidepsin
ROMIDEPSIN
romidepsin

External Source Codes: 
CAS Registry Number 128517-07-7 (see NLM ChemIDplus info)
FDA UNII Code CX3T89XQBK
ChEBI ID CHEBI:61080 (see ChEBI info)
NSC Code 630176 (see NCI DTP info)
PDQ Closed Trial Search ID 42600
PDQ Open Trial Search ID 42600 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527027

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C24H36N4O6S2
code C1544
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Depsipeptide
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1544

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