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Version: 17.06d (Release date: 2017-06-26)
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Pibrozelesin (Code C1542)

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Terms & Properties

Preferred Name: Pibrozelesin

Definition: A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.

NCI-GLOSS Definition: A semisynthetic anticancer drug that is a type of antitumor antibiotic.

Label: Pibrozelesin

NCI Thesaurus Code: C1542 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0254093  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic Acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methy-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7,-trimethoxy-1H-indol-2-yl)carbonyl)-, Methyl Ester (S)
Duocamycin B2 Analog
KW 2189

External Source Codes: 
CAS Registry Number 154889-68-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42429
PDQ Open Trial Search ID 42429 (check for NCI PDQ open clinical trial info)
UMLS CUI C0254093

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C32H36BrN5O8
code C1542
Contributing_Source FDA
Legacy_Concept_Name KW_2189
Semantic_Type Antibiotic
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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