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Version: 17.06d (Release date: 2017-06-26)
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Pibrozelesin (Code C1542)

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Terms & Properties

Preferred Name: Pibrozelesin

Definition: A semisynthetic water-soluble derivative of the antineoplastic antibiotic duocarmycin B2. Activated by carboxyl esterase, pibrozelesin alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.

NCI-GLOSS Definition: A semisynthetic anticancer drug that is a type of antitumor antibiotic.

Label: Pibrozelesin

NCI Thesaurus Code: C1542 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0254093  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic Acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methy-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7,-trimethoxy-1H-indol-2-yl)carbonyl)-, Methyl Ester (S)
Duocamycin B2 Analog
KW-2189
KW2189
KW 2189
Pibrozelesin
PIBROZELESIN

External Source Codes: 
CAS Registry Number 154889-68-6 (see NLM ChemIDplus info)
FDA UNII Code IHK933KCIC
PDQ Closed Trial Search ID 42429
PDQ Open Trial Search ID 42429 (check for NCI PDQ open clinical trial info)
UMLS CUI C0254093

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C32H36BrN5O8
code C1542
Contributing_Source FDA
Legacy_Concept_Name KW_2189
Semantic_Type Antibiotic
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1542

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