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Version: 16.11d (Release date: 2016-11-28)
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C-myb Antisense Oligonucleotide G4460 (Code C1541)

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Terms & Properties

Preferred Name: C-myb Antisense Oligonucleotide G4460

Definition: A 24-base phosphorothiolate antisense oligodeoxynucleotide (ODN) for the proto-oncogene c-myb with potential antineoplastic activity. C-myb antisense oligonucleotide G4460 binds to codon sequences 2 to 9 of c-myb mRNA, inhibiting translation of the transcript. Suppression of c-myb expression with this agent may result in the restoration of normal differentiation pathways, increased antiproliferative effects, and the induction of apoptosis in early progenitor hematopoietic cells and in tumor cells that overexpress c-myb. Tumor-cell overexpression of c-myb blocks differentiation, promotes proliferation, and inhibits apoptosis.

Label: C-myb Antisense Oligonucleotide G4460

NCI Thesaurus Code: C1541 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0253788  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
c-MYB Antisense
c-MYB Antisense Oligodeoxynucleotide
C-myb Antisense Oligonucleotide G4460
c-Myb Antisense OND
c-Myb LR-3001
G4460
INX-3001
LR-3001
OL(1)p53

External Source Codes: 
NSC Code 710296 (see NCI DTP info)
PDQ Closed Trial Search ID 43388
PDQ Open Trial Search ID 43388 (check for NCI PDQ open clinical trial info)
UMLS CUI C0253788

Other Properties:
Name Value (qualifiers indented underneath)
code C1541
Legacy_Concept_Name LR-3001
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1541

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