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Version: 17.06d (Release date: 2017-06-26)
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Tezacitabine (Code C1539)

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Terms & Properties

Preferred Name: Tezacitabine

Definition: A synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, further compromising DNA replication. This agent is relatively resistant to metabolic deactivation by cytidine deaminase. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates necessary for DNA synthesis and is overexpressed in many tumor types.

NCI-GLOSS Definition: A drug that belongs to a family of drugs called ribonucleotide reductase inhibitors.

Label: Tezacitabine

NCI Thesaurus Code: C1539 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0253087  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MDL 101,731

External Source Codes: 
CAS Registry Number 171176-43-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 354256
PDQ Open Trial Search ID 354256 (check for NCI PDQ open clinical trial info)
UMLS CUI C0253087

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H12FN3O4.H2O
code C1539
Contributing_Source FDA
Legacy_Concept_Name Tezacitabine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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