Terms & Properties

Preferred Name:  Cadonilimab

Definition:  A bispecific antibody directed against the human negative immunoregulatory checkpoint receptors programmed cell death protein 1 (PD-1; PDCD1; CD279) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, cadonilimab targets and binds to both PD-1 and CTLA4 expressed on tumor-infiltrating T lymphocytes (TILs), and inhibits the PD-1- and CTLA4-mediated downregulation of T-cell activation and proliferation. This restores immune function and activates a sustained cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-1 and CTLA4 are selectively expressed on TILs in the tumor microenvironment (TME) and negatively regulate the activation and effector functions of T-cells. They play key roles in the downregulation of the immune system and tumor evasion from host immunity. Dual checkpoint blockade of PD1 and CTLA4 with cadonilimab may enhance T-cell activation and proliferation more than the blockade of either immune checkpoint receptor alone.

Label:  Cadonilimab

NCI Thesaurus Code:  C153379 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  CL554535  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

AK 104

AK-104

AK104

Anti-PD-1 x CTLA-4 Bispecific Antibody AK104

Anti-PD-1/CTLA-4 Bispecific Antibody AK104

Anti-PD1/Anti-CTLA4 Bispecific Antibody AK104

CADONILIMAB

Cadonilimab

PD-1 x CTLA-4 Dual Checkpoint Inhibitor AK104

External Source Codes: 

CAS Registry Number	2394841-59-7 (see NLM ChemIDplus info)
NCI Drug Dictionary ID	793930 (see NCI Drug Dictionary info)
FDA UNII Code	6FYG1DS4NW
PDQ Closed Trial Search ID	793930
PDQ Open Trial Search ID	793930
NCI META CUI	CL554535

Other Properties:

Name	Value (qualifiers indented underneath)
code	C153379
Contributing_Source	FDA
Contributing_Source	GDC
Maps_To	Anti-PD-1/CTLA-4 Bispecific Antibody AK104
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C153379