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Version: 17.06d (Release date: 2017-06-26)
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Pemetrexed Disodium (Code C1533)

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Terms & Properties

Preferred Name: Pemetrexed Disodium

Definition: The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.

NCI-GLOSS Definition: A drug used alone or with another drug to treat certain types of non-small cell lung cancer and malignant pleural mesothelioma. It is being studied in the treatment of other types of cancer. Pemetrexed disodium blocks DNA synthesis and may kill cancer cells. It is a type of folate antagonist.

Display Name: Pemetrexed Disodium

Label: Pemetrexed Disodium

NCI Thesaurus Code: C1533 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0936142  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt
Pemetrexed Disodium
pemetrexed disodium

External Source Codes: 
CAS Registry Number 150399-23-8 (see NLM ChemIDplus info)
ChEBI ID CHEBI:63722 (see ChEBI info)
NSC Code 698037 (see NCI DTP info)
PDQ Closed Trial Search ID 42328
PDQ Open Trial Search ID 42328 (check for NCI PDQ open clinical trial info)
UMLS CUI C0936142

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Malignant pleural mesothelioma; Non-small cell lung cancer
Chemical_Formula C20H19N5O6.2Na
code C1533
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pemetrexed
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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