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Version: 17.06d (Release date: 2017-06-26)
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Letrozole (Code C1527)

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Terms & Properties

Preferred Name: Letrozole

Definition: A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.

NCI-GLOSS Definition: A drug used to treat advanced breast cancer in postmenopausal women. Letrozole causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor.

Display Name: Letrozole

Label: Letrozole

NCI Thesaurus Code: C1527 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0246421  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile
CGS 20267
Femara
Letrozole
letrozole
LETROZOLE

External Source Codes: 
CAS Registry Number 112809-51-5 (see NLM ChemIDplus info)
FDA UNII Code 7LKK855W8I
ChEBI ID CHEBI:6413 (see ChEBI info)
NSC Code 719345 (see NCI DTP info)
PDQ Closed Trial Search ID 42086
PDQ Open Trial Search ID 42086 (check for NCI PDQ open clinical trial info)
UMLS CUI C0246421

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hormone receptor-positive early breast cancer; Delayed puberty; Endometrial cancer; Ovulatory induction
Chemical_Formula C17H11N5
code C1527
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Letrozole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1527

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