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Version: 17.10e (Release date: 2017-10-30)
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Docetaxel (Code C1526)

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Terms & Properties

Preferred Name: Docetaxel

Definition: A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)

NCI-GLOSS Definition: A drug used together with other drugs to treat certain types of breast cancer, stomach cancer, prostate cancer, and certain types of head and neck cancer. It is also being studied in the treatment of other types of cancer. Docetaxel is a type of mitotic inhibitor.

Display Name: Docetaxel

Label: Docetaxel

NCI Thesaurus Code: C1526 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0246415  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester
Taxotere Injection Concentrate

External Source Codes: 
CAS Registry Number 148408-66-6 (see NLM ChemIDplus info)
FDA UNII Code 15H5577CQD
ChEBI ID CHEBI:59809 (see ChEBI info)
NSC Code 628503 (see NCI DTP info)
PDQ Closed Trial Search ID 41657
PDQ Open Trial Search ID 41657 (check for NCI PDQ open clinical trial info)
UMLS CUI C0246415

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Esophageal cancer; Gastric cancer; Head/Neck cancers; Locally Advanced or Metastatic Non small-cell lung cancer; Ovarian cancer; Metastatic Prostate cancer
Chemical_Formula C43H53NO14.3H2O
code C1526
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Docetaxel
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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