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Version: 17.06d (Release date: 2017-06-26)
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Liarozole Fumarate (Code C1524)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Liarozole Fumarate

Definition: The orally active fumarate salt of the benzimidazole derivative liarozole with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.

Label: Liarozole Fumarate

NCI Thesaurus Code: C1524 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0245820  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole Fumarate (2:3)
1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, (+-)-, (E)-2-butenedioate (2:3)
Liarozole Fumarate
LIAROZOLE FUMARATE
R85246

External Source Codes: 
CAS Registry Number 145858-52-2 (see NLM ChemIDplus info)
FDA UNII Code 91W7VLK7J3
PDQ Closed Trial Search ID 41252
PDQ Open Trial Search ID 41252 (check for NCI PDQ open clinical trial info)
UMLS CUI C0245820

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C17H13ClN4.3C4H4O4
code C1524
Contributing_Source FDA
Legacy_Concept_Name Liarozole_Fumarate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1524

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