skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Liarozole Fumarate (Code C1524)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Liarozole Fumarate

Definition: The orally active fumarate salt of the benzimidazole derivative liarozole with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.

Label: Liarozole Fumarate

NCI Thesaurus Code: C1524 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0245820  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole Fumarate (2:3)
1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, (+-)-, (E)-2-butenedioate (2:3)
Liarozole Fumarate

External Source Codes: 
CAS Registry Number 145858-52-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 41252
PDQ Open Trial Search ID 41252 (check for NCI PDQ open clinical trial info)
UMLS CUI C0245820

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C17H13ClN4.3C4H4O4
code C1524
Contributing_Source FDA
Legacy_Concept_Name Liarozole_Fumarate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom