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Version: 17.06d (Release date: 2017-06-26)
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Troglitazone (Code C1522)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Troglitazone

Definition: An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04)

Label: Troglitazone

NCI Thesaurus Code: C1522 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0245514  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-2,4-Thiazolidinedione
5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
CI-991
CS-045
Prelay
Rezulin
Romozin
Troglitazone
TROGLITAZONE

External Source Codes: 
CAS Registry Number 97322-87-7 (see NLM ChemIDplus info)
FDA UNII Code I66ZZ0ZN0E
ChEBI ID CHEBI:9753 (see ChEBI info)
PDQ Closed Trial Search ID 42706
PDQ Open Trial Search ID 42706 (check for NCI PDQ open clinical trial info)
UMLS CUI C0245514

Other Properties:
     Name Value (qualifiers indented underneath)
code C1522
Contributing_Source FDA
Legacy_Concept_Name Troglitazone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1522

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