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Version: 17.06d (Release date: 2017-06-26)
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Roquinimex (Code C1519)

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Terms & Properties

Preferred Name: Roquinimex

Definition: A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04)

Label: Roquinimex

NCI Thesaurus Code: C1519 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0244748  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilide
1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
FCF 89
Linomide
LS 2616
N-Phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide
ROQUINIMEX
Roquinimex

External Source Codes: 
CAS Registry Number 84088-42-6 (see NLM ChemIDplus info)
FDA UNII Code 372T2944C0
PDQ Closed Trial Search ID 41410
PDQ Open Trial Search ID 41410 (check for NCI PDQ open clinical trial info)
UMLS CUI C0244748

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H16N2O3
code C1519
Contributing_Source FDA
Legacy_Concept_Name Roquinimex
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1519

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