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Version: 17.08d (Release date: 2017-08-28)
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Raloxifene (Code C1518)

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Terms & Properties

Preferred Name: Raloxifene

Definition: A selective benzothiophene estrogen receptor modulator (SERM). Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect. This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. (NCI04)

NCI-GLOSS Definition: The active ingredient in a drug used to reduce the risk of invasive breast cancer in postmenopausal women who are at high risk of the disease or who have osteoporosis. It is also used to prevent and treat osteoporosis in postmenopausal women. It is also being studied in the prevention of breast cancer in certain premenopausal women and in the prevention and treatment of other conditions. Raloxifene blocks the effects of the hormone estrogen in the breast and increases the amount of calcium in bone. It is a type of selective estrogen receptor modulator (SERM).

Display Name: Raloxifene

Label: Raloxifene

NCI Thesaurus Code: C1518 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0752233  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LY 139481

External Source Codes: 
CAS Registry Number 84449-90-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:8772 (see ChEBI info)
PDQ Closed Trial Search ID 43109
PDQ Open Trial Search ID 43109 (check for NCI PDQ open clinical trial info)
UMLS CUI C0752233

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Breast cancer; Cardiovascular Disease prophylaxis; Osteoporosis
Chemical_Formula C28H27NO4S
code C1518
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Raloxifene
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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