Terms & Properties

Preferred Name:  Anti-TIM-3 Monoclonal Antibody Sym023

Definition:  A recombinant, fully human monoclonal antibody against the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, the anti-TIM-3 monoclonal antibody Sym023 binds to TIM-3 expressed on certain T-cells, including tumor infiltrating lymphocytes (TILs). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction in tumor cell proliferation. TIM-3, a transmembrane protein and immune checkpoint receptor, is associated with tumor-mediated immune suppression.

Display Name:  Anti-TIM-3 Monoclonal Antibody Sym023

Label:  Anti-TIM-3 Monoclonal Antibody Sym023

NCI Thesaurus Code:  C150560 (Search for linked caDSR metadata)   (search value sets)

NCI Metathesaurus Link:  CL552361  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

Anti-TIM-3 Monoclonal Antibody Sym023

Anti-TIM3 Monoclonal Antibody Sym023

Sym 023

SYM-023

Sym-023

Sym023

External Source Codes: 

NCI Drug Dictionary ID	793443 (see NCI Drug Dictionary info)
FDA UNII Code	9GEU9XHE20
PDQ Closed Trial Search ID	793443
PDQ Open Trial Search ID	793443
NCI META CUI	CL552361

Other Properties:

Name	Value (qualifiers indented underneath)
code	C150560
Contributing_Source	CTRP
Contributing_Source	FDA
Contributing_Source	GDC
Maps_To	Anti-TIM-3 Monoclonal Antibody Sym023
	Target_Terminology: GDC       Relationship_to_Target: Has Synonym       Target_Term_Type: PT       Target_Code: therapeutic_agents
Semantic_Type	Amino Acid, Peptide, or Protein
Semantic_Type	Pharmacologic Substance

Additional Concept Data: 

Defined Fully by Roles: No

URL:https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C150560