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Version: 17.12d (Release date: 2017-12-26)
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Aldesleukin (Code C1498)

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Terms & Properties

Preferred Name: Aldesleukin

Definition: A recombinant analog of the endogenous cytokine interleukin-2 (IL-2) with immunoregulatory and antineoplastic activities. Aldesleukin binds to and activates the IL-2 receptor, followed by heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains; activation of the tyrosine kinase Jak3; and phosphorylation of tyrosine residues on the IL-2R beta chain, resulting in an activated receptor complex. Various cytoplasmic signaling molecules are recruited to the activated receptor complex and become substrates for regulatory enzymes that are associated with the receptor complex. This agent enhances lymphocyte mitogenesis; stimulates long-term growth of human IL-2 dependent cell lines; enhances lymphocyte cytotoxicity; induces lymphokine-activated killer (LAK) cell and natural killer (NK) cell activities; and induces expression of interferon-gamma. Aldesleukin may induce T cell-mediated tumor regression in some tumor types.

NCI-GLOSS Definition: A drug used to treat some types of cancer. It is a form of interleukin-2, a cytokine made by leukocytes (white blood cells), that is made in the laboratory. Aldesleukin increases the activity and growth of white blood cells called T lymphocytes and B lymphocytes. It is a type of biological response modifier.

Display Name: Aldesleukin

Label: Aldesleukin

NCI Thesaurus Code: C1498 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0218986  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
125-L-Serine-2-133-interleukin 2
Recombinant Human IL-2
Recombinant Human Interleukin-2
recombinant human interleukin-2

External Source Codes: 
CAS Registry Number 110942-02-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 39756
PDQ Open Trial Search ID 39756 (check for NCI PDQ open clinical trial info)
UMLS CUI C0218986

Other Properties:
     Name Value (qualifiers indented underneath)
code C1498
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Aldesleukin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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