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Version: 16.10e (Release date: 2016-10-31)
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Satraplatin (Code C1493)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Satraplatin

Definition: An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in cell growth inhibition and apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of prostate and other types of cancer. It contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.

Display Name: Satraplatin

Label: Satraplatin

NCI Thesaurus Code: C1493 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1142934  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
(OC-6-43)-bis(acetato-O)amminedichloro(cyclohexanamine)platinum
BMS-182751
BMY-45594
JM-216
JM 216
Orplatna
platinum,bis(acetato-O)amminedichloro(cyclohexanamine)-,(OC-6-43)
Satraplatin
SATRAPLATIN
satraplatin

External Source Codes: 
CAS Registry Number 129580-63-8 (see NLM ChemIDplus info)
FDA UNII Code 8D7B37T28G
PDQ Closed Trial Search ID 42141
PDQ Open Trial Search ID 42141 (check for NCI PDQ open clinical trial info)
UMLS CUI C1142934

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C6H13N.2C2H3O2.2Cl.Pt.H3N
code C1493
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Satraplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1493

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