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Version: 17.06d (Release date: 2017-06-26)
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Sargramostim (Code C1492)

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Terms & Properties

Preferred Name: Sargramostim

Definition: A recombinant therapeutic agent chemically identical to endogenous human GM-CSF except a leucine substitution in position 23. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity.

NCI-GLOSS Definition: A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent.

Display Name: Sargramostim

Label: Sargramostim

NCI Thesaurus Code: C1492 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0216231  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
23-L-Leucinecolony-Stimulating Factor 2
DRG-0012
Leukine
Prokine
rhu GM-CFS
Sagramostim
Sargramostatin
Sargramostim
sargramostim
SARGRAMOSTIM

External Source Codes: 
CAS Registry Number 123774-72-1 (see NLM ChemIDplus info)
FDA UNII Code 5TAA004E22
PDQ Closed Trial Search ID 40566
PDQ Open Trial Search ID 40566 (check for NCI PDQ open clinical trial info)
UMLS CUI C0216231

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Melanoma; Neutropenia-chemotherapy induced
code C1492
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sargramostim
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1492

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