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Version: 17.06d (Release date: 2017-06-26)
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Rubitecan (Code C1485)

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Terms & Properties

Preferred Name: Rubitecan

Definition: A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)

NCI-GLOSS Definition: An alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors.

Label: Rubitecan

NCI Thesaurus Code: C1485 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0213800  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9-NC
9-Nitro-20(S)-camptothecin
9-nitrocamptothecin
Camptogen
Nitrocamptothecin
nitrocamptothecin
Orathecin
RFS 2000
Rubitecan
RUBITECAN

External Source Codes: 
CAS Registry Number 91421-42-0 (see NLM ChemIDplus info)
FDA UNII Code H19C446XXB
NSC Code 603070 (see NCI DTP info)
PDQ Closed Trial Search ID 42528
PDQ Open Trial Search ID 42528 (check for NCI PDQ open clinical trial info)
UMLS CUI C0213800

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For AIDs, pediatric; HIV infection, pediatric
Chemical_Formula C20H15N3O6
code C1485
Contributing_Source FDA
Legacy_Concept_Name Rubitecan
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1485

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