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Version: 17.12d (Release date: 2017-12-26)
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Milodistim (Code C1477)

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Terms & Properties

Preferred Name: Milodistim

Definition: A recombinant fusion protein derived from the coding sequences of two growth factors, interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Milodistim exhibits greater receptor binding affinity and colony stimulating activity than its parent cytokines. This agent stimulates proliferation of immature hematopoietic cells and allows the stimulation and expansion of multi-lineage hematopoiesis from immature bone marrow progenitor cells. (NCI04)

Label: Milodistim

NCI Thesaurus Code: C1477 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0211169  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
23-L-Leucine-27-L-aspartic acid-39-L-glutamic acid-colony-stimulating factor 2 (Human Clone pHG25 Protein Moiety Reduced), (127-9')-protein with 9-Glycine-10-glycine-11-glycine-12-glycine-13-L-serine-14-glycine-15-glycine-16-glycine-18-glycine-19-L-serine-34-L-aspartic acid-89-L-aspartic acid-9-152-interleukin 3 (human clone D11 Precursor Protein Moiety Reduced)
GM-CSF/IL-3 Fusion Protein
GM-CSF/IL3 Fusion Protein
Granulocyte-Macrophage Colony Stimulating Factor/Interleukin-3 Fusion Protein

External Source Codes: 
CAS Registry Number 137463-76-4 (see NLM ChemIDplus info)
NSC Code 645014 (see NCI DTP info)
PDQ Closed Trial Search ID 41615
PDQ Open Trial Search ID 41615 (check for NCI PDQ open clinical trial info)
UMLS CUI C0211169

Other Properties:
     Name Value (qualifiers indented underneath)
code C1477
Contributing_Source FDA
Legacy_Concept_Name Milodistim
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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