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Version: 16.11d (Release date: 2016-11-28)
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Filgrastim (Code C1474)

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Terms & Properties

Preferred Name: Filgrastim

Definition: A recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors.

NCI-GLOSS Definition: A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). It is a cytokine that is a type of hematopoietic (blood-forming) agent.

Display Name: Filgrastim

Label: Filgrastim

NCI Thesaurus Code: C1474 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0210630  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Filgrastim
FILGRASTIM
filgrastim
Filgrastim-sndz
Filgrastim XM02
G-CSF
Neupogen
r-metHuG-CSF
Recombinant Methionyl Human Granulocyte Colony Stimulating Factor
rG-CSF
Tbo-filgrastim
Tevagrastim
Zarxio

External Source Codes: 
CAS Registry Number 121181-53-1 (see NLM ChemIDplus info)
FDA UNII Code PVI5M0M1GW
NSC Code 614629 (see NCI DTP info)
PDQ Closed Trial Search ID 41057
PDQ Open Trial Search ID 41057 (check for NCI PDQ open clinical trial info)
UMLS CUI C0210630

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Aplastic neutropenia; Bone marrow transplantation; Cancer patients receiving myelosuppressive chemotherapy; Congenital neutropenia; Idiopathic or cyclic neutropenia; Peripheral blood progenitor cell mobilization
code C1474
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Filgrastim
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1474

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