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Version: 17.06d (Release date: 2017-06-26)
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Bizelesin (Code C1472)

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Terms & Properties

Preferred Name: Bizelesin

Definition: A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called alkylating agents. It is also an antitumor antibiotic.

Label: Bizelesin

NCI Thesaurus Code: C1472 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0209891  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzo(1,2-b:4,3-b')dipyrrol-4-ol, 6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*)))-
Benzo[1,2-b:4,3-b']dipyrrol-4-ol, 6, 6'-[carbonylbis(imino- 1H-indole-5, 2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*))]
Bizelesin
bizelesin
BIZELESIN
U-77779

External Source Codes: 
CAS Registry Number 129655-21-6 (see NLM ChemIDplus info)
FDA UNII Code L0O9OBI87E
NSC Code 615291 (see NCI DTP info)
PDQ Closed Trial Search ID 42688
PDQ Open Trial Search ID 42688 (check for NCI PDQ open clinical trial info)
UMLS CUI C0209891

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C43H36Cl2N8O5
code C1472
Contributing_Source FDA
Legacy_Concept_Name Bizelesin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1472

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