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Version: 17.06d (Release date: 2017-06-26)
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Lamivudine (Code C1471)

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Terms & Properties

Preferred Name: Lamivudine

Definition: A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. (NCI04)

NCI-GLOSS Definition: A drug used to treat infection caused by viruses.

Display Name: Lamivudine

Label: Lamivudine

NCI Thesaurus Code: C1471 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0209738  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(-)-BCH-189
2',3'-Dideoxy-3'-thiacytidine
3'-Thia-2',3'-dideoxycytidine
3TC
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
Epivir
GR109714X
LAM
Lamivudine
LAMIVUDINE
lamivudine

External Source Codes: 
CAS Registry Number 134678-17-4 (see NLM ChemIDplus info)
FDA UNII Code 2T8Q726O95
ChEBI ID CHEBI:63577 (see ChEBI info)
PDQ Closed Trial Search ID 42593
PDQ Open Trial Search ID 42593 (check for NCI PDQ open clinical trial info)
UMLS CUI C0209738

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic hepatitis B; HIV infection
Chemical_Formula C8H11N3O3S
code C1471
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lamivudine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1471

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