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Version: 17.06d (Release date: 2017-06-26)
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Mycophenolate Mofetil (Code C1468)

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Terms & Properties

Preferred Name: Mycophenolate Mofetil

Definition: The morpholinoethyl ester of mycophenolic acid (MPA) with potent immunosuppressive properties. Mycophenolate stops T-cell and B-cell proliferation through selective inhibition of the de novo pathway of purine biosynthesis. In vivo, the active metabolite, MPA, reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of guanine nucleotides. MPA displays high lymphocyte specificity and cytotoxicity due to the higher dependence of activated lymphocytes on both salvage and de novo synthesis of guanine nucleotides relative to other cell types. (NCI04)

NCI-GLOSS Definition: A drug used to prevent graft-versus-host disease (GVHD) after organ transplants. It is also being studied in the prevention of GVHD after stem cell transplants for cancer, and in the treatment of some autoimmune disorders. Mycophenolate mofetil is a type of immunosuppressive agent.

Display Name: Mycophenolate Mofetil

Label: Mycophenolate Mofetil

NCI Thesaurus Code: C1468 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0209368  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mycophenolate Mofetil
mycophenolate mofetil

External Source Codes: 
CAS Registry Number 115007-34-6 (see NLM ChemIDplus info)
CAS Registry Number 128794-94-5 (see NLM ChemIDplus info)
FDA UNII Code 9242ECW6R0
NSC Code 724229 (see NCI DTP info)
PDQ Closed Trial Search ID 42797
PDQ Open Trial Search ID 42797 (check for NCI PDQ open clinical trial info)
UMLS CUI C0209368

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Heart transplantation; Kidney transplantation; Liver transplantation; Lupus nephritis
Chemical_Formula C23H31NO7
code C1468
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Mycophenolate_Mofetil
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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