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Version: 17.06d (Release date: 2017-06-26)
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Tirapazamine (Code C1464)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tirapazamine

Definition: A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)

NCI-GLOSS Definition: A drug that makes tumor cells more sensitive to radiation therapy.

Display Name: Tirapazamine

Label: Tirapazamine

NCI Thesaurus Code: C1464 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0208407  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-Amino-1,2,4-benzotriazine-1,4-dioxide
SR4233
SR 4233
Tirapazamine
tirapazamine
TIRAPAZAMINE
Tirazone
WIN 59075

External Source Codes: 
CAS Registry Number 27314-97-2 (see NLM ChemIDplus info)
FDA UNII Code 1UD32YR59G
NSC Code 130181 (see NCI DTP info)
PDQ Closed Trial Search ID 42158
PDQ Open Trial Search ID 42158 (check for NCI PDQ open clinical trial info)
UMLS CUI C0208407

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H6N4O2
code C1464
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tirapazamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1464

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