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Version: 17.06d (Release date: 2017-06-26)
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Perillyl Alcohol (Code C1461)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Perillyl Alcohol

Definition: A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the prevention of cancer. It belongs to the family of plant drugs called monoterpenes.

CRCH Definition: A terpene with two isoprene units forming a ring and with a hydroxyl group attached to the head methyl group. The chemical structure is CC(=C)C1CCC(=CC1)CO.

Display Name: Perillyl Alcohol

Label: Perillyl Alcohol

NCI Thesaurus Code: C1461 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0207661  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-(-)-Perillyl alcohol
(S)-(-)-Perillyl Alcohol
(S)-4-Isopropenyl-1-cyclohexenylmethanol
1-Cyclohexene-1-methanol
4-(1-Methylethenyl)
4-(1-Methylethenyl)-1-cyclohexene-1-methanol
4-Isopropenylcyclohex-1-ene-1-methanol
[(4S)-4-prop-1-en-2-yl-1-cyclohexenyl]methanol
Dihydrocuminyl Alcohol
NEO100
p-Mentha-1,8-dien-7-ol
Perilla Alcohol
Perilla alcohol
Perillic alcohol
Perillic Alcohol
Perillol
Perillyl Alcohol
perillyl alcohol
PERILLYL ALCOHOL
POH

External Source Codes: 
CAS Registry Number 18457-55-1 (see NLM ChemIDplus info)
CAS Registry Number 536-59-4 (see NLM ChemIDplus info)
FDA UNII Code 319R5C7293
ChEBI ID CHEBI:15420 (see ChEBI info)
ChEBI ID CHEBI:10782 (see ChEBI info)
NSC Code 641066 (see NCI DTP info)
PDQ Closed Trial Search ID 42334
PDQ Open Trial Search ID 42334 (check for NCI PDQ open clinical trial info)
UMLS CUI C0207661

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H16O
code C1461
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Perillyl_Alcohol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1461

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