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Version: 17.06d (Release date: 2017-06-26)
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Zorubicin Hydrochloride (Code C1458)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Zorubicin Hydrochloride

Definition: A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)

Label: Zorubicin Hydrochloride

NCI Thesaurus Code: C1458 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0206788  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S-cis)-Benzoic Acid[1-[4-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide
Benzoyl Hydrazone Daunorubicin
Daunorubicin Benzoylhydrazone Hydrochloride
RP 22,050 Hydrochloride
RP 22050
Rubidazone
Zorubicin Hydrochloride
ZORUBICIN HYDROCHLORIDE
Zorubicin hydrochloride

External Source Codes: 
CAS Registry Number 36508-71-1 (see NLM ChemIDplus info)
FDA UNII Code WXM8D9M6DE
NSC Code 164011 (see NCI DTP info)
PDQ Closed Trial Search ID 39590
PDQ Open Trial Search ID 39590 (check for NCI PDQ open clinical trial info)
UMLS CUI C0206788

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H35N3O10.ClH
code C1458
Contributing_Source FDA
Legacy_Concept_Name Zorubicin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1458

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