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Version: 17.10e (Release date: 2017-10-30)
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Nafoxidine Hydrochloride (Code C1448)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nafoxidine Hydrochloride

Definition: The hydrochloride salt of the partial estrogen antagonist nafoxidine. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)

Label: Nafoxidine Hydrochloride

NCI Thesaurus Code: C1448 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0205850  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride
Nafoxidine Hydrochloride
NAFOXIDINE HYDROCHLORIDE
U 11100A
U-11,000A

External Source Codes: 
CAS Registry Number 1847-63-8 (see NLM ChemIDplus info)
FDA UNII Code SU8WBD61G1
NSC Code 70735 (see NCI DTP info)
PDQ Closed Trial Search ID 39309
PDQ Open Trial Search ID 39309 (check for NCI PDQ open clinical trial info)
UMLS CUI C0205850

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H31NO2.HCl
code C1448
Contributing_Source FDA
Legacy_Concept_Name Nafoxidine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1448

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