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Version: 17.06d (Release date: 2017-06-26)
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Sodium Phenylbutyrate (Code C1440)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sodium Phenylbutyrate

Definition: The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called differentiating agents.

Display Name: Sodium Phenylbutyrate

Label: Sodium Phenylbutyrate

NCI Thesaurus Code: C1440 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0718066  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Phenylbutyric Acid, Sodium Salt
Buphenyl
phenylbutyrate
Phenylbutyrate Sodium
Sodium 4-Phenylbutyrate
Sodium 4-phenylbutyrate
Sodium Phenylbutyrate
SODIUM PHENYLBUTYRATE
SPB11

External Source Codes: 
CAS Registry Number 1716-12-7 (see NLM ChemIDplus info)
FDA UNII Code NT6K61736T
NSC Code 657802 (see NCI DTP info)
PDQ Closed Trial Search ID 536018
PDQ Open Trial Search ID 536018 (check for NCI PDQ open clinical trial info)
UMLS CUI C0718066

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Adjunctive therapy for urea cycle disorders involving deficiencies of carbamoylphosphate synthetase; ornithine transcarbamylase; or argininosuccinic acid synthetase; S-S and S-C sickle cell disease; S-thalassemia hemoglobinopathy
Chemical_Formula C10H11O2.Na
code C1440
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _4-Phenylbutyrate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1440

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