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Version: 16.10e (Release date: 2016-10-31)
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Recombinant CD40-Ligand (Code C1437)

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Terms & Properties

Preferred Name: Recombinant CD40-Ligand

Definition: A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines. (NCI04)

Label: Recombinant CD40-Ligand

NCI Thesaurus Code: C1437 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1527003  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD154 antigen
CD40L
gp39
Recombinant CD40-Ligand
rhu CD40L
T-BAM
T-Cell Antigen gp39
TNF-Related Activation Protein
TRAP Ligand

External Source Codes: 
CAS Registry Number 147205-72-9 (see NLM ChemIDplus info)
NSC Code 696600 (see NCI DTP info)
PDQ Closed Trial Search ID 43639
PDQ Open Trial Search ID 43639 (check for NCI PDQ open clinical trial info)
UMLS CUI C1527003

Other Properties:
Name Value (qualifiers indented underneath)
code C1437
Legacy_Concept_Name Therapeutic_CD40-Ligand
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1437

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