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Version: 17.06d (Release date: 2017-06-26)
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Lobaplatin (Code C1434)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Lobaplatin

Definition: A third-generation, water-soluble platinum compound with potential antineoplastic activity. Lobaplatin forms highly reactive, charged, platinum complexes that bind to nucleophilic groups such as GC- and AG-rich sites in DNA, inducing intrastrand DNA cross-links. These cross-links will ultimately result in induction of apoptosis and cell growth inhibition. Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.

NCI-GLOSS Definition: A substance that contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.

Label: Lobaplatin

NCI Thesaurus Code: C1434 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0165747  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2-diammino-methy lcyclobutane-platinum (II) lactate
D-19466
LOBAPLATIN
Lobaplatin
lobaplatin

External Source Codes: 
CAS Registry Number 135558-11-1 (see NLM ChemIDplus info)
FDA UNII Code OX5XK1JD8C
PDQ Closed Trial Search ID 41669
PDQ Open Trial Search ID 41669 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 21034513 (see PubMed Primary Reference info)
UMLS CUI C0165747

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H14N2.C3H4O3.Pt
code C1434
Contributing_Source FDA
Legacy_Concept_Name Lobaplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1434

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