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Version: 17.06d (Release date: 2017-06-26)
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Imiquimod (Code C1431)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Imiquimod

Definition: A synthetic agent with immune response modifying activity. As an immune response modifier (IRM), imiquimod stimulates cytokine production, especially interferon production, and exhibits antitumor activity, particularly against cutaneous cancers. Imiquimod's proapoptotic activity appears to be related to Bcl-2 overexpression in susceptible tumor cells. (NCI04)

NCI-GLOSS Definition: A drug used to treat early basal cell skin cancer and certain other skin conditions. It is being studied in the treatment of other types of cancer. Imiquimod is a type of biological response modifier.

Display Name: Imiquimod

Label: Imiquimod

NCI Thesaurus Code: C1431 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0718327  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-
4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline
Aldara
Imiquimod
imiquimod
IMIQUIMOD
R 837
S 26308
Zyclara

External Source Codes: 
CAS Registry Number 99011-02-6 (see NLM ChemIDplus info)
FDA UNII Code P1QW714R7M
ChEBI ID CHEBI:36704 (see ChEBI info)
NSC Code 369100 (see NCI DTP info)
NSC Code 741062 (see NCI DTP info)
PDQ Closed Trial Search ID 38558
PDQ Open Trial Search ID 38558 (check for NCI PDQ open clinical trial info)
UMLS CUI C0718327

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Condyloma; Superficial Basal Cell Carcinoma; Actinic Keratosis
Chemical_Formula C14H16N4
code C1431
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Imiquimod
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1431

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