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Version: 17.06d (Release date: 2017-06-26)
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Perfosfamide (Code C1423)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Perfosfamide

Definition: The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)

Label: Perfosfamide

NCI Thesaurus Code: C1423 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0163054  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
4'-Hydroperoxycyclophosphamide
4-HC
4-Hydroperoxycyclophosphamide
4-Pergamid
cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide
cis-4-hydroperoxycyclophosphamide
Hydroperoxycyclophosphamide
PERFOSFAMIDE
Perfosfamide
Pergamid

External Source Codes: 
CAS Registry Number 39800-16-3 (see NLM ChemIDplus info)
FDA UNII Code U880A4FUDA
ChEBI ID CHEBI:196991 (see ChEBI info)
NSC Code 181815 (see NCI DTP info)
PDQ Closed Trial Search ID 40474
PDQ Open Trial Search ID 40474 (check for NCI PDQ open clinical trial info)
UMLS CUI C0163054

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Ex-vivo treatment of autologous bone marrow and subsequent reinfusion in patients with acute myelogenous leukemia
Chemical_Formula C7H15Cl2N2O4P
code C1423
Contributing_Source FDA
Legacy_Concept_Name Perfosfamide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1423

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