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Version: 17.06d (Release date: 2017-06-26)
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Rifabutin (Code C1408)

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Terms & Properties

Preferred Name: Rifabutin

Definition: A semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. (NCI04)

NCI-GLOSS Definition: A drug used to prevent the spread of a bacterium called in patients with advanced HIV (the virus that causes AIDS) infection. It blocks an enzyme that the bacteria need to grow. It is a type of antibiotic.

Label: Rifabutin

NCI Thesaurus Code: C1408 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0140575  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 72559-06-9 (see NLM ChemIDplus info)
ChEBI ID CHEBI:45367 (see ChEBI info)
PDQ Closed Trial Search ID 37812
PDQ Open Trial Search ID 37812 (check for NCI PDQ open clinical trial info)
UMLS CUI C0140575

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Prevention and treatment of Mycobacterium avium complex (MAC) and tuberculosis in patients with HIV infection
Chemical_Formula C46H62N4O11
code C1408
Contributing_Source FDA
Legacy_Concept_Name Rifabutin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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