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Version: 16.11d (Release date: 2016-11-28)
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Valspodar (Code C1405)

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Terms & Properties

Preferred Name: Valspodar

Definition: An analogue of cyclosporin-A. Valspodar inhibits p-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activity of some drugs in some drug-resistant tumor cells. This agent also induces caspase-mediated apoptosis. (NCI04)

NCI-GLOSS Definition: A substance that is being studied for its ability to prevent or overcome the resistance of tumor cells to some anticancer drugs. It belongs to the family of drugs called cyclosporine analogs.

Display Name: Valspodar

Label: Valspodar

NCI Thesaurus Code: C1405 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0753474  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]cyclosporin D
Amdray
Cyclo((2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl)-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-me
PSC-833
PSC 833
SZD PSC 833
Valspodar
VALSPODAR

External Source Codes: 
CAS Registry Number 121584-18-7 (see NLM ChemIDplus info)
FDA UNII Code Q7ZP55KF3X
NSC Code 648265 (see NCI DTP info)
PDQ Closed Trial Search ID 41750
PDQ Open Trial Search ID 41750 (check for NCI PDQ open clinical trial info)
UMLS CUI C0753474

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C63H111N11O12
code C1405
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Valspodar
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1405

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