skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Piperazinedione (Code C1401)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Piperazinedione

Definition: A crystalline antibiotic fermentation product isolated from the bacterium Streptomyces griseoluteus with antineoplastic activity. Piperazinedione alkylates DNA at the N-7 position of guanine, inhibiting DNA replication and inducing cell cycle arrest.

Label: Piperazinedione

NCI Thesaurus Code: C1401 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0888240  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2,5-Piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3.alpha.(2S*,5R*),6.alpha.(2S*,5R*)]]- (9CI)
2,5-piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3alpha(2S*,5R*),6alpha(2S*,5R*)]]- (9CI)
2, 5-piperazinedione, 3,6-bis-(5-chloro-2-piperidyl)-, dihydrochloride
2, 5-Piperazinedione, 3,6-bis-(5-chloro-2-piperidyl)-, dihydrochloride
593A
Compound 593A
Merck Compound 593A
Piperazinedione
PZD
PZD dihydrochloride, 3,6-bis(5-chloro-2-piperidinyl)-, dihydrochloride

External Source Codes: 
CAS Registry Number 41109-80-2 (see NLM ChemIDplus info)
NSC Code 135758 (see NCI DTP info)
PDQ Closed Trial Search ID 39556
PDQ Open Trial Search ID 39556 (check for NCI PDQ open clinical trial info)
UMLS CUI C0888240

Other Properties:
     Name Value (qualifiers indented underneath)
code C1401
Legacy_Concept_Name Piperazinedione
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1401

Mainbox Bottom