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Version: 16.11d (Release date: 2016-11-28)
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Peplomycin (Code C1399)

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Terms & Properties

Preferred Name: Peplomycin

Definition: A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)

Label: Peplomycin

NCI Thesaurus Code: C1399 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0135981  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide
n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamide
PEP
PEPLEOMYCIN
Pepleomycin
PEPLOMYCIN
Peplomycin

External Source Codes: 
CAS Registry Number 68247-85-8 (see NLM ChemIDplus info)
FDA UNII Code 56H9L80NIZ
NSC Code 276382 (see NCI DTP info)
PDQ Closed Trial Search ID 39552
PDQ Open Trial Search ID 39552 (check for NCI PDQ open clinical trial info)
UMLS CUI C0135981

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C61H88N18O21S2
code C1399
Contributing_Source FDA
Legacy_Concept_Name Peplomycin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Antibiotic

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1399

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