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Version: 17.06d (Release date: 2017-06-26)
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Sparfosic Acid (Code C1398)

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Terms & Properties

Preferred Name: Sparfosic Acid

Definition: A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable transition analogue of the activated complex for the reaction catalyzed by aspartate transcarbamylase, the first step in the pyrimidine biosynthetic pathway. This agent inhibits de novo pyrimidine biosynthesis and increases the extent to which fluorouracil metabolites are incorporated into RNA.

NCI-GLOSS Definition: An anticancer drug that is being studied to increase the effectiveness of the chemotherapy drug fluorouracil.

Label: Sparfosic Acid

NCI Thesaurus Code: C1398 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0135096  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Aspartic acid, N-(phosphonoacetyl)-
N-Phosphonacetyl-L-aspartate
N-phosphonacetyl-L-aspartate
PALA
Phosphonacetyl-L-aspartic Acid
Sparfosate
SPARFOSIC ACID
Sparfosic Acid

External Source Codes: 
CAS Registry Number 51321-79-0 (see NLM ChemIDplus info)
FDA UNII Code 78QVZ7RG8L
NSC Code 224131 (see NCI DTP info)
PDQ Closed Trial Search ID 39547
PDQ Open Trial Search ID 39547 (check for NCI PDQ open clinical trial info)
UMLS CUI C0135096

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6H10NO8P
code C1398
Contributing_Source FDA
Legacy_Concept_Name N-Phosphonacetyl-L-aspartate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1398

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