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Version: 16.11d (Release date: 2016-11-28)
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Vinorelbine Tartrate (Code C1395)

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Terms & Properties

Preferred Name: Vinorelbine Tartrate

Definition: The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. (NCI04)

NCI-GLOSS Definition: A drug used to treat advanced non-small cell lung cancer. It blocks cell growth by stopping cell division and may cause cancer cells to die. It is a type of vinca alkaloid and a type of antimitotic agent.

Display Name: Vinorelbine Tartrate

Label: Vinorelbine Tartrate

NCI Thesaurus Code: C1395 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0377401  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Biovelbin
Eunades
KW-2307
Navelbine
Navelbine Ditartrate
Navelbine ditartrate
NVB
Vinorelbine Ditartrate
Vinorelbine Tartrate
VINORELBINE TARTRATE
vinorelbine tartrate

External Source Codes: 
CAS Registry Number 125317-39-7 (see NLM ChemIDplus info)
FDA UNII Code 253GQW851Q
ChEBI ID CHEBI:32296 (see ChEBI info)
NSC Code 608210 (see NCI DTP info)
PDQ Closed Trial Search ID 40449
PDQ Open Trial Search ID 40449 (check for NCI PDQ open clinical trial info)
UMLS CUI C0377401

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Non-small cell lung cancer; metastatic breast cancer; uterine and cervical cancer; desmoid tumors; advanced Kaposi's sarcoma
Chemical_Formula C45H54N4O8.2C4H6O6
code C1395
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Vinorelbine_Ditartrate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1395

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